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Tadalafil is definitely an efficacious treatment for ED of all severities and etiologies. The largest data series exists for the general ED population with mild to moderate ED (Brock et al 2002a; Carson et al 2004a), but tadalafil has also been confirmed to be an effective answer to difficult-to-treat ED such as worse, organic ED evaluated in tertiary care centers (Carson et al 2005a), ED secondary to Diabetes mellitus (Saenz de Tejada et al 2002; Fonseca et al 2004), and ED caused by prostate type of cancer treatments like prostatectomy (Montorsi et al 2004; Carson et al 2005b) and radiotherapy (Incrocci et al 2007).

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